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Ephedrine / Caffeine / Aspirin Stack

The effects of the ECA Stack (Ephedrine, Caffeine and Aspirin) in weight loss are primarily due to the Ephedrine component but not its sole reason by any means. Ephedrine acts both as a Beta Receptor Agonist and stimulates the release of norepinephrine and adrenaline into your system.

Ephedrine Definition
Pronounced US: Ef Fed Reen.
Pronounced UK: Effer Drin.
Checmical: C10 H15 NO

A white, odorless crystalline alkaloid or powder.
Isolated from shrubs of the genus Ephedra or made synthetically. It is used in the treatment of allergies and asthma.
Ref. Dictionary.

Caffeine Definition
Pronounced: Caffeen.
Checmical: C8 H10 N4 O2

A bitter white alkaloid often derived from tea or coffee and used in medicine chiefly as a mild stimulant and to treat certain kinds of headache.
Ref. Dictionary

Aspirin Definition
Pronounced: As Per In.
Chemical: C9 H8 O4
A white, crystalline compound, , derived from salicylic acid and commonly used in tablet form to relieve pain and reduce fever and inflammation, also known as acetyl salicylic acid.
Ref. Dictionary


This increases the circulating norepinephrine in the body, which then acts on white Adipose tissue (fatty tissue) by increasing cAMP (Cyclic Adenosine MonoPhosphate) levels.

This causes a thermogenic effect, raising body temperature and increasing the user's metabolism in conjunction with the rest of the stack (Caffeine and Aspirin).

However, the body's Negative Feedback system (self defense) then activates to normalize the metabolism. This is done via the production of Phosphodiesterase inside the cells, and prostaglandins outside the cell, which both lower cAMP levels within the cell and neutralising the effects.

Caffeine is used to inhibit the production of phosphodiesterase inside the cell and therefore slows cAMP breakdown. It also binds with and competitively inhibits adenosine receptors in the brain, triggering the release of epinephrine and increasing cAMP levels further.

So it prolongs the break down and thus effect of the ephedrine while simultaniously having its own energy boosting effect.

Aspirin inhibits prostaglandin production outside of the cells, which, in conjunction with caffeine working inside the cell, greatly prolongs the thermogenic effects and increased metabolism by sustaining elevated cAMP levels. Many people find they don't need the Aspirin in an ECA Stack which maybe true but its monetary cost means its effective to use it for maximum results.

The way that the 3 products work, means they are Synergistic, which is rather than 1+1+1=3 its more like 3+2+2=7, so the 3 products when combined are stronger and longer lasting than they are alone.

This is called Synergenic Effect, and much similar to how fuels are mixed to boost a cars performance.

Ephedrine also has an Anorectic, or Appetite Suppressant effect. However, these effects only last for about two weeks if the stack is not cycled, as the body becomes tolerant to ephedrine to some degree.

You can prolong this by using upregulators which are usually certain anti-histamines such as Diphenhydramine or Ketotifen. It is estimated that 50%–65% of the weight loss from using the ECA Stack comes from the anorectic effect, and 20%-30% from thermogenesis and the remainder from increase assertion that the stimulant provides.

The final component in weight loss of the ECA stack is that of a simple Stimulant; the higher epinephrine and norepinephrine levels result in increased aerobic exercise performance and less fatigue, This means you can work harder, heavier and faster in the gym, speeding up calorie use and weight loss as well as enhasing your performance.


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